ICA-121431 Inhibitor

Name: ICA-121431 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752481
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752481

ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ICA-121431, Inhibitor

Full Product Name

ICA-121431

Product Gene Name

ICA-121431, inhibitor

Product Synonym Names

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

449.55

Formula

C23H19N3O3S2

CAS

313254-51-2

Smiles

O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)C(c1ccccc1)c1ccccc1

Receptor (IC50)

Nav1.7: 19nM

Solubility

DMSO: 44mg/mL (97.88mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for ICA-121431, inhibitor

Home; Membrane transporter/Ion Channel

Product References and Citations for ICA-121431, inhibitor

1. Song G, Yang D, Wang Y, et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators[J]. Nature, 2017.
2. Mccormack K, Santos S, Chapman M L, et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels[J]. Proceedings of the National Academy of Sciences, 2013, 110 (29):E2724-E2732.

Other Notes

Small volumes of ICA-121431, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ICA-121431 purchase

MBS5752481 is an inhibitor targeting ICA-121431.