NNC-0640 Inhibitor

Name: NNC-0640 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752505
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752505

NNC-0640 is a negative allosteric modulator of Human Glucagon Receptor with an IC50 of 69.2nM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NNC-0640, Inhibitor

Full Product Name

NNC-0640

Product Gene Name

NNC-0640, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

573.67

Formula

C29H31N7O4S

CAS

307986-98-7

Smiles

CS(=O)(=O)c1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)Nc2nn[nH]n2)c2ccc(cc2)C2CCCCC2)c1

Receptor (IC50)

Human Glucagon Receptor: 69.2nM

Solubility

(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for NNC-0640, inhibitor

Home; GPCR/G Protein; Glucagon Receptor

Product References and Citations for NNC-0640, inhibitor

1. Song G, Yang D, Wang Y, et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators[J]. Nature, 2017.
2. Jazayeri A, Doré, Andrew S, Lamb D, et al. Extra-helical binding site of a glucagon receptor antagonist[J]. Nature, 2016.
3. Zhang H, et al. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. 2017 Jun 8;546 (7657):259-264.

Other Notes

Small volumes of NNC-0640, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NNC-0640 purchase

MBS5752505 is an inhibitor targeting NNC-0640.