Talarozole Inhibitor

Name: Talarozole Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752509
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752509

Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46nM, respectively.Talarozole for the treatment of acne, psoriasis and other keratinization… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Talarozole, Inhibitor

Full Product Name

Talarozole

Product Synonym Names

R115866

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

377.51

Formula

C21H23N5S

CAS

201410-53-9

Smiles

CCC(CC)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1

Receptor (IC50)

RAMBA, CYP

Solubility

DMSO: 36mg/mL (95.36mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Talarozole, inhibitor

Home; Autophagy; Autophagy

Product References and Citations for Talarozole, inhibitor

1. Elizabeth Pavez Loriè, Chamcheu J C, Vahlquist A, et al. Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis[J]. Archives of Dermatological Research, 2009, 301 (7):475-485.
2. Elizabeth Pavez Loriè, Li H, Vahlquist A, et al. The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes[J]. Biochim Biophys Acta, 2009, 1791 (3):0-228.
3. Diaz P, et al. Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, theHuman Liver Retinoic Acid Hydroxylase. J Med Chem. 2016 Mar 24;59 (6):2579-95.
4. Tripathy S, et al.All-Trans-Retinoic Acid Enhances Mitochondrial Function in Models of Human Liver. Mol Pharmacol. 2016 May;89 (5):560-74.

Other Notes

Small volumes of Talarozole, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Talarozole purchase

MBS5752509 is an inhibitor targeting Talarozole.