A-836339 Inhibitor

A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64nM) over the central CB1 receptor (Ki = 270nM). It displays analgesic, anti-inflammatory, and anti-hyperalgesic effects in mice.

1. Characterization of a Cannabinoid CB2 Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3- (2-Methoxy-ethyl)-4,5-dimethyl-3H-thiazol- (2Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 328 (1):141-151.
2. Mcgaraughty S, Chu K M, Yao B, et al. A CB 2, receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB 2, receptors[J]. Neuroscience, 2009, 158 (4):1652-1661.

Small volumes of A-836339, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752511 is an inhibitor targeting A-836339.