2-D08 Inhibitor

2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49nM.2-D08 showed anti-aggregatory and neuroprotective effect.

1. Kim Y, Nagy K, Keyser S, et al. An Electrophoretic Mobility Shift Assay Identifies a Mechanistically Unique Inhibitor of Protein Sumoylation[J]. Chemistry & Biology, 2013, 20 (4):604-613.
2. Marsh D T, Das S, Ridell J, et al. Structure-activity relationships for flavone interactions with amyloid beta reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08).[J]. Bioorganic & Medicinal Chemistry, 2017, 25 (14).
3. Kim Y S, Keyser S G L, Schneekloth J S. Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an Inhibitor of Protein Sumoylation[J]. Bioorganic & medicinal chemistry letters, 2014, 24 (4).
4. Ghosh H, et al. Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission. Nat Commun. 2016 Nov 7;7:13365. doi: 10.1038/ncomms13365.
5. Fujino N, et al. Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype. Lab Invest. 2017 Sep;97 (9):1047-1062.

Small volumes of 2-D08, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752514 is an inhibitor targeting 2-D08.