GSK805 Inhibitor

Name: GSK805 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752519
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752519

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORgammat) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA binding More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GSK805, Inhibitor

Full Product Name

GSK805

Product Gene Name

GSK805, inhibitor

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

532.36

Formula

C23H18Cl2F3NO4S

CAS

1426802-50-7

Smiles

CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1

Receptor (IC50)

RORgammat

Solubility

DMSO: 100mg/mL (187.84mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for GSK805, inhibitor

Home; Metabolism; ROR; GSK805

Product References and Citations for GSK805, inhibitor

1. Xiao S, Yosef N, Yang J, et al. Small-Molecule RORgammat Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms[J]. Immunity, 2014, 40 (4):477-489.
2. Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORgammat Inhibitors[J]. ACS Medicinal Chemistry Letters:-.

Other Notes

Small volumes of GSK805, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK805 purchase

MBS5752519 is an inhibitor targeting GSK805.