ONC212 Inhibitor

MBS5752527 is an inhibitor targeting ONC212. ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132.

1. Nii T, Prabhu VV, Ruvolo V,et al.Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia[J].Leukemia. 2019 Dec;33 (12):2805-2816.
2. Lev A, Lulla A R, Wagner J, et al. Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP.[J]. Oncotarget, 2017, 8 (47):81776-81793.
3. Takenobu Nii, et al. The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199. ASH. 2017.
4. Wagner J, et al. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle. 2017 Oct 2;16 (19):1790-1799.

Small volumes of ONC212, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.