Cefepime Inhibitor

Cefepime is an antibiotic. Cefepime has been shown to be effective against febrile neutropenia.

Tamma PD, Girdwood SC, Gopaul R, Tekle T, Roberts AA, Harris AD, Cosgrove SE, Carroll KC. The use of cefepime for treating AmpC beta-lactamase-producing Enterobacteriaceae. Clin Infect Dis. 2013 Sep;57(6):781-8. doi: 10.1093/cid/cit395. Epub 2013 Jun 11. PubMed PMID: 23759352.
Saito H, Takahashi K, Okuno M, Saka H, Imaizumi K, Hasegawa Y, Tanikawa Y, Yamamoto M, Taniguchi H, Shindoh J, Suzuki R, Shimokata K; Central Japan Lung Study Group. Cefepime monotherapy for febrile neutropenia in patients with lung cancer. J Infect Chemother. 2014 Jun;20(6):365-9. doi: 10.1016/j.jiac.2014.02.002. Epub 2014 Mar 26. PubMed PMID: 24679653.
Fugate JE, Kalimullah EA, Hocker SE, Clark SL, Wijdicks EF, Rabinstein AA. Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy. Crit Care. 2013 Nov 7;17(6):R264. doi: 10.1186/cc13094. PubMed PMID: 24200036; PubMed Central PMCID: PMC4057506.
Nguyen HM, Shier KL, Graber CJ. Determining a clinical framework for use of cefepime and beta-lactam/beta-lactamase inhibitors in the treatment,of infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae. J Antimicrob Chemother. 2014 Apr;69(4):871-80. doi: 10.1093/jac/dkt450. Epub 2013 Nov 20. Review. PubMed PMID: 24265230.

Small volumes of Cefepime, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752569 is an inhibitor targeting Cefepime.