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Voruciclib Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752606

Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626nM-9.1nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the transcriptional regulator of MCL-1. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Voruciclib, Inhibitor
Full Product Name
Voruciclib
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
469.84
Solubility
DMSO: 125mg/mL (266.05mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H19ClF3NO5
SMILES
O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C(O)=CC(O)=C13
CAS Number
1000023-04-0
Target & IC50
DK9/cyc T2: ic50 0.626nM (ki)
CDK9/CycT1: ic50 1.68nM (ki)
CDK6/cycD1: ic50 2.92nM (ki)
CDK4/Cyc D1: ic50 3.96nM (ki)
CDK1/cycB: ic50 5.4nM (ki)
CDK1/cyc A: ic50 9.1nM (ki)

Product References and Citations for Voruciclib, inhibitor

1. Dey J, et al. Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition. Sci Rep. 2017 Dec 21;7(1):18007.

Other Notes

Small volumes of Voruciclib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Voruciclib purchase

MBS5752606 is an inhibitor targeting Voruciclib.
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