4-Methylamino antipyrine Inhibitor

Name: 4-Methylamino antipyrine Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752627
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752627

4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak anti-inflammatory properties. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

4-Methylamino antipyrine, Inhibitor

Full Product Name

4-Methylamino antipyrine

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

217.27

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C12H15N3O

SMILES

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1NC

CAS Number

519-98-2

Target & IC50

COX

In Vitro

Eight healthy male piglets are administered Metamizole (100mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 hours. The average maximum concentration of 4-Methylamino antipyrine is 47.59mg/mL. The average half-lives is 8.57 hours for 4-Methylamino antipyrine [1].

Product Categories/Family for 4-Methylamino antipyrine, inhibitor

Immunology/Inflammation; COX; Neuroscience

Product References and Citations for 4-Methylamino antipyrine, inhibitor

BurmaA, czuk A, et al. Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets. J Vet Pharmacol Ther. 2016 Dec;39(6):616-620.
BurmaA, czuk A, et al. Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets. J Vet Pharmacol Ther. 2016 Dec;39(6):616-620.
Campos C1, et al. Regulation of cyclooxygenase activity by metamizol. Eur J Pharmacol. 1999 Aug 13;378(3):339-47.
Campos C1, et al. Regulation of cyclooxygenase activity by metamizol. Eur J Pharmacol. 1999 Aug 13;378(3):339-47.
Ariza A, et al. Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole. Sci Rep. 2016 Mar 31;6:23845.
Ariza A, et al. Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole. Sci Rep. 2016 Mar 31;6:23845.

Other Notes

Small volumes of 4-Methylamino antipyrine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 4-Methylamino antipyrine purchase

MBS5752627 is an inhibitor targeting 4-Methylamino antipyrine.