5-Iodo-indirubin-3'-monoxime Inhibitor

Name: 5-Iodo-indirubin-3'-monoxime Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752632
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752632

5-Iodo-indirubin-3'-monoxime is a potent GSK-3beta, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20 and 25nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

5-Iodo-indirubin-3'-monoxime, Inhibitor

Full Product Name

5-Iodo-indirubin-3'-monoxime

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

403.17

Solubility

DMSO: 67.5mg/mL (167.42mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C16H10IN3O2

SMILES

O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=C(I)C=C4)=O

CAS Number

331467-03-9

Target & IC50

GSK-3beta: ic50 9nM
Cdk5/p25: ic50 20nM
Cdk1/cyclin B: ic50 25nM

Product Categories/Family for 5-Iodo-indirubin-3'-monoxime, inhibitor

PI3K/Akt/mTOR signaling; Stem Cells; Cell Cycle/Checkpoint

Product References and Citations for 5-Iodo-indirubin-3'-monoxime, inhibitor

Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors, J Biol Chem. 2001 Jan 5;276(1):251-60.
Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors J Biol Chem. 2001 Jan 5;276(1):251-60.

Other Notes

Small volumes of 5-Iodo-indirubin-3'-monoxime, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 5-Iodo-indirubin-3'-monoxime purchase

MBS5752632 is an inhibitor targeting 5-Iodo-indirubin-3'-monoxime.