ACY-957 Inhibitor

Name: ACY-957 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752663
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752663

ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7nM, 18nM, and 1300nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACY-957, Inhibitor

Full Product Name

ACY-957

Product Gene Name

ACY-957, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

429.54

Solubility

DMSO: 83.33mg/mL (194.00mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H23N5OS

SMILES

O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N

CAS Number

1609389-52-7

Target & IC50

HDAC1: ic50 7nM
HDAC2: ic50 18nM
HDAC3: ic50 1300nM

In Vitro

ACY-957 has an IC50 of 304nM for HDAC2 in primary hematopoietic progenitors.

Product Categories/Family for ACY-957, inhibitor

Chromatin/Epigenetic; HDAC; DNA Damage/DNA Repair

Product References and Citations for ACY-957, inhibitor

Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11(4):e0153767.
Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11(4):e0153767.

Other Notes

Small volumes of ACY-957, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACY-957 purchase

MBS5752663 is an inhibitor targeting ACY-957.