ADU-S100 Inhibitor – Disodium Salt

Name: ADU-S100 Inhibitor; Disodium Salt; MyBioSource
Brand: MyBioSource
SKU: MBS5752666
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752666

ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ADU-S100 disodium salt, Inhibitor

Full Product Name

ADU-S100 disodium salt

Product Gene Name

ADU-S100, inhibitor

Product Synonym Names

MIW815 disodium salt;mL RR-S2 CDA disodium salt

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

734.51

Solubility

H2O: 300mg/mL (408.44mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H22N10Na2O10P2S2

SMILES

[O-]C([C@](CO[P@]1(S)=O)([H])O2)([H])[C@](O[P@](S)(OC[C@](O[C@@H](N3C4=NC=NC(N)=C4N=C3)[C@@H]5[O-])([H])[C@@]5([H])O1)=O)([H])[C@@H]2N6C7=NC=NC(N)=C7N=C6.[Na+].[Na+]

CAS Number

1638750-95-4

Target & IC50

STING

Cell Research

Cryopreserved hPBMCs are thawed and 1x10^6 cells per well are plated in a 96 well plate in RPMI media supplemented with 10% FBS, 1% non-essential amino acids, 1% penicillin/streptomycin, L-glutamine, 10mM HEPES buffer, 1mM Sodium Pyruvate, 0.055mM beta-ME at 37 degree C with 5% CO2. Cells are stimulated with 10uM ADU-S100 ormL cGAMP for 6 hours and supernatants are harvested. Supernatants are diluted 1:2 and assayed for IFN-alpha protein using Cytometric Bead Array (CBA) Human Flex Set. Data is collected using a FACSVerse cytometer.

In Vitro

ADU-S100 shows higher anti-tumor control than the endogenousmL cGAMP. A dose-response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicits maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%.

Product Categories/Family for ADU-S100, inhibitor

Immunology/Inflammation

Product References and Citations for ADU-S100, inhibitor

Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30.
Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30.

Other Notes

Small volumes of ADU-S100, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADU-S100 purchase

MBS5752666 is an inhibitor targeting ADU-S100. Also known as ADU-S100 disodium salt.