Anatabine dicitrate Inhibitor

Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent alpha4beta2 nAChR agonist and inhibits NF-kappaB activation lower amyloid-beta (Abeta) production by preventing the beta-cleavage of the amyloid precursor protein.

Paris D, et al. Anatabine lowers Alzheimer's Abeta production in vitro and in vivo. Eur J Pharmacol. 2011 Nov 30;670(2-3):384-91.
Paris D, et al. Anatabine lowers Alzheimer's Abeta production in vitro and in vivo. Eur J Pharmacol. 2011 Nov 30;670(2-3):384-91.
Xing H, et al. A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine. Mar Drugs. 2020 Feb 11;18(2). pii: E106.
Xing H, et al. A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine. Mar Drugs. 2020 Feb 11;18(2). pii: E106.
eo EJ, et al. Phytochemicals as inhibitors of NF-kappaB for treatment,of Alzheimer's disease. Pharmacol Res. 2018 Mar;129:262-273.
eo EJ, et al. Phytochemicals as inhibitors of NF-kappaB for treatment,of Alzheimer's disease. Pharmacol Res. 2018 Mar;129:262-273.

Small volumes of Anatabine dicitrate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752692 is an inhibitor targeting Anatabine dicitrate.