APX-115 Inhibitor

Name: APX-115 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752704
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752704

APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 uM, 0.57uM, and 0.63uM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

APX-115, Inhibitor

Full Product Name

APX-115 free base

Product Gene Name

APX-115, inhibitor

Product Synonym Names

Ewha-18278 free base

Form/Format

Solid. Powder

Purity/Purification

99.03%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

279.34

Solubility

DMSO: 245mg/ml (877.07mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C17H17N3O

SMILES

CCCC1=C(NN(C1=O)C1=CC=CC=N1)C1=CC=CC=C1

CAS Number

1270084-92-8

Target & IC50

Nox1: ic50 1.08uM (ki)
Nox2: ic50 0.57uM (ki)
Nox4(ki): ic50 0.63uM (ki)

Product Categories/Family for APX-115, inhibitor

Immunology/Inflammation; NADPH-oxidase

Product References and Citations for APX-115, inhibitor

Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.
Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.
Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.
Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.

Other Notes

Small volumes of APX-115, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APX-115 purchase

MBS5752704 is an inhibitor targeting APX-115. Also known as APX-115 free base.