APX-115 Inhibitor

Name: APX-115 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752705
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752705

APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 uM, 0.57 uM, and 0.63uM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

APX-115, Inhibitor

Full Product Name

APX-115

Product Gene Name

APX-115, inhibitor

Product Synonym Names

Ewha-18278

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

315.8

Solubility

DMSO: 250mg/mL (791.64mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C17H18ClN3O

SMILES

OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3.Cl

CAS Number

1395946-75-4

Target & IC50

Nox1: ic50 1.08uM (ki)
Nox2: ic50 0.57uM (ki)
Nox4(ki): ic50 0.63uM (ki)

Product Categories/Family for APX-115, inhibitor

Immunology/Inflammation; NADPH-oxidase

Product References and Citations for APX-115, inhibitor

Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.
Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.
Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.
Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.

Other Notes

Small volumes of APX-115, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APX-115 purchase

MBS5752705 is an inhibitor targeting APX-115.