AS2863619 Inhibitor

Name: AS2863619 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752724
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752724

AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61nM and 4.28nM). STAT5 activation enhanced by AS2863619 free base… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AS2863619, Inhibitor

Full Product Name

AS2863619 free base

Product Gene Name

AS2863619, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

332.32

Solubility

DMSO: 250mg/mL (752.29mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C16H12N8O

SMILES

NC1=NON=C1C(N2C3=CC=C4N=C(C)NC4=C3)=NC5=C2C=CN=C5

CAS Number

2241300-50-3

Target & IC50

CDK8: ic50 0.61nM
CDK19: ic50 4.28nM
GSK3alpha: ic50 76.67nM
GSK3beta: ic50 63.06nM
STAT5

Product Categories/Family for AS2863619, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for AS2863619, inhibitor

Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707.
Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707.

Other Notes

Small volumes of AS2863619, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AS2863619 purchase

MBS5752724 is an inhibitor targeting AS2863619. Also known as AS2863619 free base.