ASP-AMS Inhibitor

Name: ASP-AMS Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752727
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752727

Asp-AMS is a strong competitive inhibitor of the mitochondrial enzyme and also an aspartyl-tRNA synthetase inhibitor. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Asp-AMS, Inhibitor

Full Product Name

Asp-AMS

Product Gene Name

Asp-AMS, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

461.41

Solubility

DMSO: 100mg/mL (216.73mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C14H19N7O9S

SMILES

O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COS(=O)(NC([C@@H](N)CC(O)=O)=O)=O

CAS Number

828288-98-8

Target & IC50

Aspartyl-tRNA synthetase, Mitochondrial enzyme

In Vitro

Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300nM). Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with Ki values in the nanomolar range, with a stronger effect on bacterial AspRSs (E Coli and P. aeruginosa) than on human cytosolic AspRS.

Product References and Citations for Asp-AMS, inhibitor

Messmer M, et al. Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs. Biochimie. 2009 May;91(5):596-603.
Messmer M, et al. Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs. Biochimie. 2009 May;91(5):596-603.

Other Notes

Small volumes of Asp-AMS, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Asp-AMS purchase

MBS5752727 is an inhibitor targeting Asp-AMS.

ASP-AMS Inhibitor

Product Overview

Related Product Information for Asp-AMS, inhibitor

Product References and Citations for Asp-AMS, inhibitor

Other Notes

Searchable Terms for Asp-AMS purchase