AZ12601011 Inhibitor

Name: AZ12601011 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752744
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752744

AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18nM; Kd: 2.9nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting TGFBR1, ALK4, and ALK7. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZ12601011, Inhibitor

Full Product Name

AZ12601011

Product Gene Name

AZ12601011, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

313.36

Solubility

DMSO: 5mg/mL (15.96mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H15N5

SMILES

C1(C2=NC=CC=C2)=NC(N3C=CC4=C3C=CN=C4)=C(CCC5)C5=N1

Target & IC50

TGFBR1: ic50 2.9nM (kd)
ALK4

In Vitro

In vivo, AZ12601011 (50mg/kg; oral gavage; twice daily; for 25 days) inhibits tumor growth and metastasis.

Product Categories/Family for AZ12601011, inhibitor

Angiogenesis; ALK; Tyrosine Kinase/Adaptors

Product References and Citations for AZ12601011, inhibitor

Spender LC, et al. Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor betaSuperfamily Type 1 Receptors. Mol Pharmacol. 2019 Feb;95(2):222-234.
Spender LC, et al. Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor betaSuperfamily Type 1 Receptors. Mol Pharmacol. 2019 Feb;95(2):222-234.

Other Notes

Small volumes of AZ12601011, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZ12601011 purchase

MBS5752744 is an inhibitor targeting AZ12601011.