AZD-0364 Inhibitor

Name: AZD-0364 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752747
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752747

AZD-0364 is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1 (example 18; IC50: 0.6nM). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZD-0364, Inhibitor

Full Product Name

AZD-0364

Product Gene Name

AZD-0364, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

494.5

Solubility

DMSO: 100mg/mL (202.22mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H24F2N8O2

SMILES

O=C1C2=NC(C3=NC(NC4=CC=NN4C)=NC=C3C)=CN2C[C@H](COC)N1CC5=CC=C(F)C(F)=C5

CAS Number

2097416-76-5

Target & IC50

ERK2: ic50 0.6nM

In Vitro

In the A549 xenograft model, Selumetinib is dosed twice daily (BiD) 8 hours apart and AZD-0364 ethanesulfonic acid is dosed once daily (QD) 4 hours after the first Selumetinib dose. Both compounds are dosed continuously for 3 weeks. Both vehicles are dosed in the vehicle group. Both Selumetinib and AZD-0364 ethanesulfonic acid reduce tumor growth relative to vehicle-only control. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growthours.

Product Categories/Family for AZD-0364, inhibitor

MAPK; ERK

Product References and Citations for AZD-0364, inhibitor

WARD, Richard, Andrew, et al. DIHYDROIMIDAZOPYRAZINONE DERIVATIVES USEFUL IN THE treatment,OF CANCER. WO2017080979A1.
WARD, Richard, Andrew, et al. DIHYDROIMIDAZOPYRAZINONE DERIVATIVES USEFUL IN THE treatment,OF CANCER. WO2017080979A1.

Other Notes

Small volumes of AZD-0364, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZD-0364 purchase

MBS5752747 is an inhibitor targeting AZD-0364.