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TAK1/MAP4K21 Inhibitor – TAK1/MAP4K2 1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752757

TAK1/MAP4K2 inhibitor 1 is a potent dual inhibitor of TGFbeta-activated kinase 1 (TAK1) and MAP4K2 (IC50s: 41.1nM and 18.2nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TAK1/MAP4K2 1 (TAK1/MAP4K21), Inhibitor
Full Product Name
TAK1/MAP4K2 inhibitor 1
Product Gene Name
TAK1/MAP4K21, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
552.59
Solubility
DMSO: 50mg/mL (90.48mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C29H31F3N6O2
SMILES
CC(N1)=CC2=C1N=CN=C2OC3=C(C)C=CC(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)=C3
CAS Number
1315330-11-0
Target & IC50
TAK1: ic50 41.1nM
MAP4K2: ic50 18.2nM
In Vitro
TAK1/MAP4K2 inhibitor 1 (1mg/kg, iv) has moderate terminal elimination half-life (t1/2=2.94 h) in mice.

Structure of TAK1/MAP4K21, inhibitor

TAK1/MAP4K21 Inhibitor – Cat# MBS5752757

Product References and Citations for TAK1/MAP4K21, inhibitor

Tan L, et al. Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96.
Tan L, et al. Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96.

Other Notes

Small volumes of TAK1/MAP4K21, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAK1/MAP4K21 purchase

MBS5752757 is an inhibitor targeting TAK1/MAP4K21. Also known as TAK1/MAP4K2 inhibitor 1.
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