BAY-1797 Inhibitor

Name: BAY-1797 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752767
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752767

BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displays no or very weak activity on the other P2X ion channels. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BAY-1797, Inhibitor

Full Product Name

BAY-1797

Product Gene Name

BAY-1797, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

416.88

Solubility

DMSO: 250mg/mL (599.69mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H17ClN2O4S

SMILES

O=C(NC1=CC=C(OC2=CC=CC(Cl)=C2)C(S(=O)(N)=O)=C1)CC3=CC=CC=C3

CAS Number

2055602-83-8

Target & IC50

human P2X4: ic50 211nM
human P2X1: ic50 >50uM
human P2X23: ic50 >30uM
human P2X3: ic50 8.3uM
human P2X7: ic50 10.6uM

In Vitro

BAY-1797 (12.5-50mg/kg; p.o.) shows a significant induction of PGE2 levels in the inflamed paw in the mouse Complete Freund's Adjuvant (CFA) inflammatory pain model. BAY-1797 (50mg/kg; once daily for multiple p.o.) induces a significant reduction of the ipsilateral paw load 24 and 48 hours after CFA injection. BAY-1797 treatment,shows the AUCnorm, Vss, and t1/2 are 1.06 kg h/L, 3.67L/kg, and 2.64 hours, respectively.

Product Categories/Family for BAY-1797, inhibitor

Neuroscience; P2 Receptor

Product References and Citations for BAY-1797, inhibitor

Werner S, et al. Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile. J Med Chem. 2019 Dec 26;62(24):11194-11217.
Werner S, et al. Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile. J Med Chem. 2019 Dec 26;62(24):11194-11217.

Other Notes

Small volumes of BAY-1797, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAY-1797 purchase

MBS5752767 is an inhibitor targeting BAY-1797.