Beclabuvir Inhibitor

Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 <28nM).

Gentile I, et al. Beclabuvir for the treatment,of hepatitis C. Expert Opin Investig Drugs. 2015;24(8):1111-21
Gentile I, et al. Beclabuvir for the treatment,of hepatitis C. Expert Opin Investig Drugs. 2015;24(8):1111-21
Tatum H, et al. A randomized, placebo-controlled study of the NS5B inhibitor beclabuvir with peginterferon/ribavirin for HCV genotype 1. J Viral Hepat. 2015 Aug;22(8):658-64.
Tatum H, et al. A randomized, placebo-controlled study of the NS5B inhibitor beclabuvir with peginterferon/ribavirin for HCV genotype 1. J Viral Hepat. 2015 Aug;22(8):658-64.

Small volumes of Beclabuvir, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752787 is an inhibitor targeting Beclabuvir.