BI-2852 Inhibitor

Name: BI-2852 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752793
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752793

BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BI-2852, Inhibitor

Full Product Name

BI-2852

Product Gene Name

BI-2852, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

516.59

Solubility

DMSO: 100mg/mL (193.58mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C31H28N6O2

SMILES

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62)N7)=C1C7=O

CAS Number

2375482-51-0

Target & IC50

KRAS(G12C): ic50 450nM
KRAS G12C: ic50 750nM (kd)

Product Categories/Family for BI-2852, inhibitor

MAPK; Ras

Product References and Citations for BI-2852, inhibitor

Kessler D, et al. Drugging an undruggable pocket on KRAS. Proc Natl Acad Sci U S A. 2019 Aug 6; 116(32):15823-15829.
Kessler D, et al. Drugging an undruggable pocket on KRAS. Proc Natl Acad Sci U S A. 2019 Aug 6; 116(32):15823-15829.

Other Notes

Small volumes of BI-2852, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BI-2852 purchase

MBS5752793 is an inhibitor targeting BI-2852.