Biotin-VAD-FMK Inhibitor

Name: Biotin-VAD-FMK Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752798
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752798

Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Biotin-VAD-FMK, Inhibitor

Full Product Name

Biotin-VAD-FMK

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

672.81

Solubility

DMSO: 27.3mg/mL (40.58mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C30H49FN6O8S

SMILES

COC(C[C@@H](C(CF)=O)NC([C@H](C)NC([C@H](C(C)C)NC(CCCCCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)=O)=O)=O)=O

CAS Number

1135688-15-1

Target & IC50

Caspase

In Vitro

Biotin-VAD-FMK can facilitate cell permeability.

Product Categories/Family for Biotin-VAD-FMK, inhibitor

Apoptosis; Caspase; Proteases/Proteasome

Product References and Citations for Biotin-VAD-FMK, inhibitor

Li J, et al. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem. 1999 Jun 11;274(24):17325-33.
Li J, et al. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem. 1999 Jun 11;274(24):17325-33.
Samraj AK, et al. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membranedepolarization. Mol Biol Cell. 2007 Jan;18(1):84-93.
Samraj AK, et al. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membranedepolarization. Mol Biol Cell. 2007 Jan;18(1):84-93.

Other Notes

Small volumes of Biotin-VAD-FMK, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Biotin-VAD-FMK purchase

MBS5752798 is an inhibitor targeting Biotin-VAD-FMK.