BMT-145027 Inhibitor

Name: BMT-145027 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752810
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752810

BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50: 47nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BMT-145027, Inhibitor

Full Product Name

BMT-145027

Product Gene Name

BMT-145027, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

438.83

Solubility

DMSO: 2.4mg/mL (5.47mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H14ClF3N4

SMILES

ClC(C(C(F)(F)F)=C1)=CC=C1C2=NNC3=NC(C4=CC=CC=C4)=C(C#N)C(C5CC5)=C32

CAS Number

2018282-44-3

Target & IC50

mGluR5: ic50 47nM

In Vitro

After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30mg/kg, with an apparent trend in novel object preference at 10mg/kg. Satellite animals indicate a total plasma concentration of 2800nM at 30mg/kg.

Product Categories/Family for BMT-145027, inhibitor

Neuroscience; GluR

Product References and Citations for BMT-145027, inhibitor

Hill MD, et al. Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators. ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086.
Hill MD, et al. Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators. ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086.

Other Notes

Small volumes of BMT-145027, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMT-145027 purchase

MBS5752810 is an inhibitor targeting BMT-145027.