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BRD0705 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752826

BRD0705 is a potent, paralog selective and orally active GSK3alpha inhibitor (IC50: 66nM; Kd: 4.8 uM). BRD0705 displays increased selectivity for GSK3alpha (8-fold) versus GSK3beta (IC50: 515nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BRD0705, Inhibitor
Full Product Name
BRD0705
Product Gene Name
BRD0705, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
321.42
Solubility
DMSO: 300mg/mL (933.36mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H23N3O
SMILES
O=C1C2=C(N=C3C([C@]2(CC)C4=CC=CC=C4)=CNN3)CC(C)(C)C1
CAS Number
2056261-41-5
Target & IC50
GSK3alpha: ic50 4.8uM (kd)
GSK-3beta(WT): ic50 515nM
In Vitro
In AML mouse models, BRD0705 (30mg/kg; oral gavage; twice daily; NSG mice) treatment,impairs leukemia initiation and prolongs survival.

Structure of BRD0705, inhibitor

BRD0705 Inhibitor – Cat# MBS5752826

Product References and Citations for BRD0705, inhibitor

Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.
Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.

Other Notes

Small volumes of BRD0705, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BRD0705 purchase

MBS5752826 is an inhibitor targeting BRD0705.
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