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BRM/BRG1ATP-1 Inhibitor – BRM/BRG1 ATP-1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752829

BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BRM/BRG1 ATP-1 (BRM/BRG1ATP-1), Inhibitor
Full Product Name
BRM/BRG1 ATP Inhibitor-1
Product Gene Name
BRM/BRG1ATP-1, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
318.27
Solubility
DMSO: 250mg/mL (785.50mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C11H9F3N4O2S
SMILES
FC1=CC(NC(NC2=CC(C(F)F)=NS2)=O)=C(CO)C=N1
CAS Number
2270879-17-7
Target & IC50
BRM, BRG1: ic50 <0.005uM

Product References and Citations for BRM/BRG1ATP-1, inhibitor

Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the treatment,of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172
Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the treatment,of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172

Other Notes

Small volumes of BRM/BRG1ATP-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BRM/BRG1ATP-1 purchase

MBS5752829 is an inhibitor targeting BRM/BRG1ATP-1. Also known as BRM/BRG1 ATP Inhibitor-1.
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