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CA2+ Inhibitor – Ca2+ Channel Agonist 1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752846

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23uM and 3.34uM) and is used as a potential treatment, for motor nerve terminal dysfunction. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ca2+ channel agonist 1, Inhibitor
Full Product Name
Ca2+ channel agonist 1
Product Gene Name
Ca2+, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
354.45
Solubility
DMSO: 50mg/mL (141.06mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H26N6O
SMILES
CC[C@@H](NC1=NC(NCC2=CC=CC=C2)=C3C(N(CCC)C=N3)=N1)CO
CAS Number
1402821-24-2
Target & IC50
CDK2: ic50 3.34uM (EC50)
N-Type Ca2+ Channel: ic50 14.23uM (EC50)
In Vitro
Ca2+ channel agonist 1 (Compound 13d) exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.

Structure of Ca2+, inhibitor

CA2+ Inhibitor – Cat# MBS5752846

Product References and Citations for Ca2+, inhibitor

Liang M, et al. Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist. ACS Med Chem Lett. 2012 Oct 1;3(12):985-990.
Liang M, et al. Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist. ACS Med Chem Lett. 2012 Oct 1;3(12):985-990.

Other Notes

Small volumes of Ca2+, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ca2+ purchase

MBS5752846 is an inhibitor targeting Ca2+. Also known as Ca2+ channel agonist 1.
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