Calcifediol-D6 Inhibitor

Calcifediol-D6 is the deuterated form of Calcifediol, which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 by the enzyme cholecalciferol 25-hydroxylase.

Teitelbaum SL. Calcifediol (25-hydroxyvitamin D3) in the treatment,of uremic bone disease. Ann Intern Med. 1981 Mar;94(3):404-5.
Teitelbaum SL. Calcifediol (25-hydroxyvitamin D3) in the treatment,of uremic bone disease. Ann Intern Med. 1981 Mar;94(3):404-5.
Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Effects of calcifediol on calcified tissue in uremia. Arch Intern Med. 1978 May 15;138 Spec No:864-5.
Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Effects of calcifediol on calcified tissue in uremia. Arch Intern Med. 1978 May 15;138 Spec No:864-5.
Recker R, Schoenfeld P, Letteri J, Slatopolsky E, Goldsmith R, Brickman A. The efficacy of calcifediol in renal osteodystrophy. Arch Intern Med. 1978 May 15;138 Spec No:857-6
Recker R, Schoenfeld P, Letteri J, Slatopolsky E, Goldsmith R, Brickman A. The efficacy of calcifediol in renal osteodystrophy. Arch Intern Med. 1978 May 15;138 Spec No:857-63.
Teitelbaum SL, Bone JM, Stein PM, Gilden JJ, Bates M, Boisseau VC, Avioli LV. Calcifediol in chronic renal insufficiency. Skeletal response. JAMA. 1976 Jan 12;235(2):164-7.
Teitelbaum SL, Bone JM, Stein PM, Gilden JJ, Bates M, Boisseau VC, Avioli LV. Calcifediol in chronic renal insufficiency. Skeletal response. JAMA. 1976 Jan 12;235(2):164-7.

Small volumes of Calcifediol-D6, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752848 is an inhibitor targeting Calcifediol-D6.