Camalexin Inhibitor

Name: Camalexin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752853
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752853

Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce ROS production. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Camalexin, Inhibitor

Full Product Name

Camalexin

Form/Format

Solid. Powder

Purity/Purification

99.84%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

200.26

Solubility

DMSO: 120mg/mL (599.22mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C11H8N2S

SMILES

C12=C(C=CC=C2)NC=C1C3=NC=CS3

CAS Number

135531-86-1

Target & IC50

ROS

In Vitro

Camalexin shows antiproliferative activity against a human breast cancer cell line. For the oomycetes, Phytophthora and Pythium Nep1-like proteins are the initial triggers of Camalexin synthesis and formation of ROS. ROS appear to be of general relevance for Camalexin formation. In a screen for enhanced susceptibility to Alternaria brassicicola the esa1 mutant is identified, which shows delayed Camalexin induction. Particularly in response to ROS inducing agents reduced Camalexin levels are synthesized. This crucial role for ESA1 is confirmed by the inability of esa1 mutants to synthesize Camalexin in response to Leptosphaeria maculans [2].

Product Categories/Family for Camalexin, inhibitor

Immunology/Inflammation

Product References and Citations for Camalexin, inhibitor

William A. Ayer, et al. Synthesis of camalexin and related phytoalexins. Tetrahedron. Volume 48, Issue 14, 1992, Pages 2919-2924.
William A. Ayer, et al. Synthesis of camalexin and related phytoalexins. Tetrahedron. Volume 48, Issue 14, 1992, Pages 2919-2924.
Glawischnig E. Camalexin. Phytochemistry. 2007 Feb;68(4):401-6.
Glawischnig E. Camalexin. Phytochemistry. 2007 Feb;68(4):401-6.
Mezencev R, et al. Antiproliferative and cancer chemopreventive activity of phytoalexins: focus on indole phytoalexins from crucifers. Neoplasma. 2003;50(4):239-45.
Mezencev R, et al. Antiproliferative and cancer chemopreventive activity of phytoalexins: focus on indole phytoalexins from crucifers. Neoplasma. 2003;50(4):239-45.

Other Notes

Small volumes of Camalexin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Camalexin purchase

MBS5752853 is an inhibitor targeting Camalexin.

Additional Details

NCBI/Uniprot data below describe general gene information for Camalexin. It may not necessarily be applicable to this product.

Protein Family

Bifunctional dihydrocamalexate synthase/camalexin synthase

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.