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CB1151 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752870

CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 with anti-tumor effects. It inhibits MCF-7 cell growth (IC50: 0.82nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CB1151, Inhibitor
Full Product Name
CB1151
Product Gene Name
CB1151, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
446.66
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C28H46O4
SMILES
C[C@]1(CCC/2)[C@](CC[C@@H]1[C@@H](C)OCCC(CC)(CC)O)([H])C2=C\C=C(C[C@@H](O)C[C@@H]3O)/C3=C
CAS Number
182369-28-4
Target & IC50
Others
In Vitro
CB1151 (0-100nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [3H]-thymidine incorporation (IC50: 0.82nM). CB1151 (0-100nM; 40 hours) exhibits activation of the IP9-type VD response element (EC50: 1.2nM), the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC50: 3.2nM) in MCF-7 cells transfected with the CAT reporter [1]. CB1151 shows a functional dissociation constant (Kdf) value of 3.6nM. The ligand concentration that provides 50% of the protease-resistant VDR fragment is defined by Kdf [2].

Structure of CB1151, inhibitor

CB1151 Inhibitor – Cat# MBS5752870

Product References and Citations for CB1151, inhibitor

Mork Hansen C, et al. The potent anti-proliferative effect of 20-epi analogues of 1,25 dihydroxyvitamin D3 in human breast-cancer MCF-7 cells is related to promoter selectivity. Int J Cancer. 1996 Sep 4;67(5):739-42.
Mork Hansen C, et al. The potent anti-proliferative effect of 20-epi analogues of 1,25 dihydroxyvitamin D3 in human breast-cancer MCF-7 cells is related to promoter selectivity. Int J Cancer. 1996 Sep 4;67(5):739-42.
Nayeri S, et al. High-affinity nuclear receptor binding of 20-epi analogues of 1,25-dihydroxyvitamin D3 correlates well with gene activation.J Cell Biochem. 1996 Sep 1;62(3):325-33.
Nayeri S, et al. High-affinity nuclear receptor binding of 20-epi analogues of 1,25-dihydroxyvitamin D3 correlates well with gene activation.J Cell Biochem. 1996 Sep 1;62(3):325-33.

Other Notes

Small volumes of CB1151, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CB1151 purchase

MBS5752870 is an inhibitor targeting CB1151.
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