CDK4/6-IN-2 Inhibitor

Name: CDK4/6-IN-2 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752888
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752888

CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor (IC50s: 2.7 and 16nM) extracted from patent US20180000819A1 (Compound 1). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CDK4/6-IN-2, Inhibitor

Full Product Name

CDK4/6-IN-2

Product Gene Name

CDK4/6-IN-2, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

506.59

Solubility

DMSO: 5.2mg/mL (10.26mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C27H32F2N8

SMILES

CCN1CCN(CC2=CN=C(NC3=NC=C(F)C(C4=CC(N(C(C)C)C(C)=N5)=C5C(F)=C4)=C3)N=C2)CC1

CAS Number

1800506-48-2

Target & IC50

CDK4: ic50 2.7nM
CDK6: ic50 16nM

In Vitro

CDK4/6-IN-2 inhibits H441, H358, PC3, MV-4-11, JeKo-1, SW780, and HGC-27 cells (IC50s: 147.8, 290.9, 260.5, 139, 36.98, 162.5, and 316.4nM).

Product Categories/Family for CDK4/6-IN-2, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for CDK4/6-IN-2, inhibitor

Frank Wu, et al. Kinase inhibitor and use thereof. US20180000819A1.
Frank Wu, et al. Kinase inhibitor and use thereof. US20180000819A1.

Other Notes

Small volumes of CDK4/6-IN-2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDK4/6-IN-2 purchase

MBS5752888 is an inhibitor targeting CDK4/6-IN-2.