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Cevipabulin fumarate Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752906

Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40nM in the human tumor cell line). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Cevipabulin fumarate, Inhibitor
Full Product Name
Cevipabulin fumarate
Product Synonym Names
TTI-237 fumarate
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
580.89
Solubility
DMSO: 50mg/mL (86.07mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H22ClF5N6O5
SMILES
C[C@@H](C(F)(F)F)NC1=C(C2=C(F)C=C(OCCCNC)C=C2F)C(Cl)=NC3=NC=NN13.O=C(O)/C=C/C(O)=O
CAS Number
849550-67-0
Target & IC50
microtubule in human tumor cells: ic50 18-40nM
In Vitro
In mice, Cevipabulin (5, 10, 15, and 20mg/kg, every 4 days for 4 cycles; i.v. and p.o.) is active against human tumor xenografts and showing dose-dependent effects, with good antitumor activity at 20 and 15mg/kg [1].

Structure of Cevipabulin fumarate, inhibitor

Cevipabulin fumarate Inhibitor – Cat# MBS5752906

Product References and Citations for Cevipabulin fumarate, inhibitor

Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300.
Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300.
Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both DB01229-like and Leurocristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9.
Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both DB01229-like and Leurocristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9.

Other Notes

Small volumes of Cevipabulin fumarate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cevipabulin fumarate purchase

MBS5752906 is an inhibitor targeting Cevipabulin fumarate.
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