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CNT2-1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752934

CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2; IC50: 640nM for hCNT2). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNT2-1, Inhibitor
Full Product Name
CNT2 inhibitor-1
Product Gene Name
CNT2-1, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
448.47
Solubility
DMSO: 75mg/mL (167.24mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C23H24N6O4
SMILES
OC[C@@H]1[C@H]([C@H]([C@H](N2C(NCC3=CC=C(C4=CC=CC=C4)C=C3)=NC5=C2N=CN=C5N)O1)O)O
CAS Number
880155-70-4
Target & IC50
hCNT2: ic50 640nM
In Vitro
CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2'-deoxy-5-fluorouridine, phlorizin, and 7,8,3'-trihydroxyflavone, which are well-known hCNT2 inhibitors.

Structure of CNT2-1, inhibitor

CNT2-1 Inhibitor – Cat# MBS5752934

Product References and Citations for CNT2-1, inhibitor

Tatani K, et al. Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8.

Other Notes

Small volumes of CNT2-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNT2-1 purchase

MBS5752934 is an inhibitor targeting CNT2-1. Also known as CNT2 inhibitor-1.
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