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Cobimetinib R-enantiomer Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752936

Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cobimetinib R-enantiomer, Inhibitor
Full Product Name
Cobimetinib R-enantiomer
Product Synonym Names
GDC-0973 R-enantiomer; XL-518 R-enantiomer
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
531.31
Solubility
DMSO: 100mg/mL (188.21mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H21F3IN3O2
SMILES
FC1=C(F)C=CC(C(N2CC([C@H]3CCCCN3)(O)C2)=O)=C1NC4=CC=C(I)C=C4F
CAS Number
934660-94-3
Target & IC50
Others

Structure of Cobimetinib R-enantiomer, inhibitor

Cobimetinib R-enantiomer Inhibitor – Cat# MBS5752936

Product References and Citations for Cobimetinib R-enantiomer, inhibitor

Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.

Other Notes

Small volumes of Cobimetinib R-enantiomer, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cobimetinib R-enantiomer purchase

MBS5752936 is an inhibitor targeting Cobimetinib R-enantiomer.
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