COH34 Inhibitor

Name: COH34 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752938
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752938

COH34 is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50: 0.37nM). COH34 binds to the catalytic domain of PARG (Kd: 0.547 uM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

COH34, Inhibitor

Full Product Name

COH34

Product Gene Name

COH34, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

293.38

Solubility

DMSO: 16.67mg/mL (56.82mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H15NOS

SMILES

CC1=CC=C(S/N=C/C2=C3C=CC=CC3=CC=C2O)C=C1

CAS Number

906439-72-3

Target & IC50

PARG: ic50 0.37nM

In Vitro

COH34 induces lethality in cancer cells with DNA repair defects. It shows antitumor activity in xenograft mouse cancer models.

Product Categories/Family for COH34, inhibitor

Exocytosis

Product References and Citations for COH34, inhibitor

Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.

Other Notes

Small volumes of COH34, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COH34 purchase

MBS5752938 is an inhibitor targeting COH34.