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CSN5i-3 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752955

CSN5i-3 is an effective, selective, oral CSN5 inhibitor that can inhibit CSN-catalyzed Cul1 adenylation with IC50 value of 5.8nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CSN5i-3, Inhibitor
Full Product Name
CSN5i-3
Product Gene Name
CSN5i-3, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
505.56
Solubility
DMSO: 100mg/mL (197.80mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C28H29F2N5O2
SMILES
O=C(C1=CC(C(F)F)=NN1C(C)C)NC2=CC(C3=CC=CC=C3)=C([C@@H]4N5C(CCC[C@@H]4O)=CN=C5)C=C2
Target & IC50
CSN5: ic50 5.8nM
In Vitro
CSN5i-3 shows good pharmacokinetic characteristics. CSN5i-3 inhibits the growth of human xenografts. treatment with CSN5i-3 triggered the formation of cleaved PARP and cleaved caspase 3, indicating apoptosis induction.

Structure of CSN5i-3, inhibitor

CSN5i-3 Inhibitor – Cat# MBS5752955

Product References and Citations for CSN5i-3, inhibitor

Schlierf A, et al. Targeted inhibition of the COP9 signalosome for treatment,of cancer. Nat Commun. 2016 Oct 24;7:13166.
Schlierf A, et al. Targeted inhibition of the COP9 signalosome for treatment,of cancer. Nat Commun. 2016 Oct 24;7:13166.

Other Notes

Small volumes of CSN5i-3, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CSN5i-3 purchase

MBS5752955 is an inhibitor targeting CSN5i-3.
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