CXCR2-IN-1 Inhibitor

Name: CXCR2-IN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752959
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752959

CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CXCR2-IN-1, Inhibitor

Full Product Name

CXCR2-IN-1

Product Gene Name

CXCR2-IN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

476.35

Solubility

DMSO: 5.4mg/mL (11.34mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H20Cl2FN3O4S

SMILES

ClC1=CC=C(NC(NC2=CC=CC(F)=C2Cl)=O)C(O)=C1S(=O)(C3CCN(C)CC3)=O

CAS Number

1873376-49-8

Target & IC50

CXCR2: ic50 9.3 (pIC50)

In Vitro

CXCR2-IN-1 has shown efficacy in oral copper ketone-induced demyelination models by oral administration, providing evidence to support CXCR2 as a potential therapeutic target for the treatment of demyelinating diseases such as multiple sclerosis.

Product Categories/Family for CXCR2-IN-1, inhibitor

Autophagy; CXCR; GPCR/G Protein; Immunology/Inflammation

Product References and Citations for CXCR2-IN-1, inhibitor

Xu H, et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential treatment,of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.
Xu H, et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential treatment,of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.

Other Notes

Small volumes of CXCR2-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCR2-IN-1 purchase

MBS5752959 is an inhibitor targeting CXCR2-IN-1.