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D8-MMAD Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752978

MBS5752978 is an inhibitor targeting D8-MMAD. D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer. More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
D8-MMAD, Inhibitor
Full Product Name
D8-MMAD
Product Gene Name
D8-MMAD, inhibitor
Product Synonym Names
Demethyldolastatin 10 D8; Monomethylauristatin D D8
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
779.11
Solubility
DMSO: 100mg/mL (128.35mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C41H58D8N6O6S
SMILES
O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@@H](OC)[C@H]3N(C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])NC([C@H](C(C)C)NC)=O)=O)C)=O)CCC3
Target & IC50
Others
In Vitro
The resulting antibody-drug conjugate (ADC) showed complete tumor regression in rodents. Their toxicological characteristics in rats have also been improved.

Structure of D8-MMAD, inhibitor

D8-MMAD Inhibitor – Cat# MBS5752978

Product References and Citations for D8-MMAD, inhibitor

Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.
Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.

Other Notes

Small volumes of D8-MMAD, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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