DHODH-IN-11 Inhibitor

Name: DHODH-IN-11 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753011
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753011

DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DHODH-IN-11, Inhibitor

Full Product Name

DHODH-IN-11

Product Gene Name

DHODH-IN-11, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

265.27

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C15H11N3O2

SMILES

O\N=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1

CAS Number

1263303-95-2

Target & IC50

DHODH: ic50 5.03 (pKa)

In Vitro

A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure.

Product Categories/Family for DHODH-IN-11, inhibitor

Metabolism

Product References and Citations for DHODH-IN-11, inhibitor

Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.
Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.

Other Notes

Small volumes of DHODH-IN-11, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DHODH-IN-11 purchase

MBS5753011 is an inhibitor targeting DHODH-IN-11.