DLK-IN-1 Inhibitor

Name: DLK-IN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753024
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753024

DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days of administration, its concentration… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DLK-IN-1, Inhibitor

Full Product Name

DLK-IN-1

Product Gene Name

DLK-IN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

423.43

Solubility

DMSO: 62.5mg/mL (147.60mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H24F3N5O2

SMILES

CC(N1C([C@@H]2[C@]3([H])[C@@]2([H])CN(C4COC4)C3)=CC(C5=CN=C(N)C(OC(F)(F)F)=C5)=N1)C

CAS Number

1620574-24-4

Target & IC50

DLK(ki): ic50 3nM (ki)

Product Categories/Family for DLK-IN-1, inhibitor

DNA Damage/DNA Repair; DNA Alkylation

Product References and Citations for DLK-IN-1, inhibitor

Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.
Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.

Other Notes

Small volumes of DLK-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DLK-IN-1 purchase

MBS5753024 is an inhibitor targeting DLK-IN-1.