DS16570511 Inhibitor

Name: DS16570511 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753047
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753047

DS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DS16570511, Inhibitor

Full Product Name

DS16570511

Product Gene Name

DS16570511, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

562.44

Solubility

DMSO: 125mg/mL (222.25mM) Need ultrasonic
DMSO: 124mg/mL (220.47mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C30H25Cl2N3O4

SMILES

Cc1onc(c1CNc1cccc(c1)C(=O)c1cn(CCCC(O)=O)c2ccccc12)-c1c(Cl)cccc1Cl

Target & IC50

Mitochondrial calcium uniporter

In Vitro

DS16570511 dose - dependent inhibition of serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 M.DS16570511 inhibits the uptake of isolated Ca2+. mitochondria from human cells, rat heart and pig heart[1].

Product Categories/Family for DS16570511, inhibitor

Membrane transporter/Ion channel; Calcium Channel

Product References and Citations for DS16570511, inhibitor

Kon N, et al. DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporter. Cell Death Discov. 2017 Jul 17;3:17045.
Kon N, et al. DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporter. Cell Death Discov. 2017 Jul 17;3:17045.

Other Notes

Small volumes of DS16570511, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DS16570511 purchase

MBS5753047 is an inhibitor targeting DS16570511.