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E-7386 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753061

MBS5753061 is an inhibitor targeting E-7386. E-7386 is an oral active CBP/ -catenin modulator. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E-7386, Inhibitor
Full Product Name
E-7386
Product Gene Name
E-7386, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
725.85
Solubility
Methanol: 250mg/mL (344.42mM) Need ultrasonic
DMSO: 125mg/mL (172.21mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C39H48FN9O4
SMILES
O=C(N([C@](CN1CC2=NC(N3CC(N4CCN(CC)CC4)C3)=CC=C2)([H])N5[C@@H](CC6=CC=C(O)C=C6F)C1=O)N(CC=C)CC5=O)NCC7=CC=CC=C7
CAS Number
1799824-08-0
Target & IC50
CBP/beta-catenin
In Vitro
E-7386 is an oral active CBP/ -catenin regulator, which can induce T cells to infiltrate into the tumor in the Wnt1 tumor cogene mouse model and enhance the anti-tumor activity of anti-PD-1 monoclonal antibody. In the Wnt1 model, t-cell infiltration in the vehicle control group was limited, while t-cell infiltration in the E-7386 treatment, group was obvious, and E-7386 showed significant anti-tumor activity.

Product Categories/Family for E-7386, inhibitor

Chromatin/Epigenetic; Epigenetic Reader Domain

Structure of E-7386, inhibitor

E-7386 Inhibitor – Cat# MBS5753061

Product References and Citations for E-7386, inhibitor

Yusaku Hori, et al. E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. Cancer Res 2017;77(13 Suppl):Abstract nr 5172.
Yusaku Hori, et al. E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. Cancer Res 2017;77(13 Suppl):Abstract nr 5172.

Other Notes

Small volumes of E-7386, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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