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LHF-535 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753063

MBS5753063 is an inhibitor targeting LHF-535. LHF-535 is an antiviral compound. It has EC50s of More details

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Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LHF-535, Inhibitor
Full Product Name
LHF-535
Product Gene Name
LHF-535, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
412.52
Solubility
DMSO: 96.67mg/mL (234.34mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C27H28N2O2
SMILES
OC(C)(C)C1=CC=C(/C=C\C2=CC=C3C(N=CN3C4=CC=C(OC(C)C)C=C4)=C2)C=C1
CAS Number
1450929-77-7
Target & IC50
Others
In Vitro
An increase in survival is also observed when the first dose of LHF-535 (10mg/kg) is delayed by 1, 2, or 3 days after infection, demonstrating that LHF-535 is efficacious as a post-exposure therapeutic in mice. LHF-535 (3, 10 or 30mg/kg; orally; daily; 14 days) protects mice from a lethal challenge with Tacaribe virus and dramatically reduces viral titers in plasma, spleen, and liver[2].

Structure of LHF-535, inhibitor

LHF-535 Inhibitor – Cat# MBS5753063

Product References and Citations for LHF-535, inhibitor

Dongcheng Dai, et al. Antiviral drugs for treatment,of arenavirus infection. WO2013123215A2.
Dongcheng Dai, et al. Antiviral drugs for treatment,of arenavirus infection. WO2013123215A2.
Madu IG, et al. A potent Lassa virus antiviral targets an arenavirus virulence determinant. PLoS Pathog. 2018 Dec 21;14(12):e1007439.
Madu IG, et al. A potent Lassa virus antiviral targets an arenavirus virulence determinant. PLoS Pathog. 2018 Dec 21;14(12):e1007439.

Other Notes

Small volumes of LHF-535, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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