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EG00229 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753070

EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3uM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. EG00229 is a neuropilin 1 (NRP1) receptor antagonist. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EG00229, Inhibitor
Full Product Name
EG00229
Product Gene Name
EG00229, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
611.6
Solubility
DMSO: 41.4mg/mL (67.69mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H20F3N7O7S3
SMILES
N=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)C=CS1)=O.O=C(O)C(F)(F)F
CAS Number
1210945-69-9
Target & IC50
125I-VEGF-A binding to PAE/NRP1: ic50 8uM
bt-VEGF-A binding to purified NRP1 b1 domain: ic50 3uM
In Vitro
EG00229 treatment, substantially reduces tumor growth and visible vascularization.

Structure of EG00229, inhibitor

EG00229 Inhibitor – Cat# MBS5753070

Product References and Citations for EG00229, inhibitor

Jarvis A, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26.
Jarvis A, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26.
Grun D, et al. VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 2016 Aug 18;35(33):4379-87.
Grun D, et al. VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 2016 Aug 18;35(33):4379-87.

Other Notes

Small volumes of EG00229, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EG00229 purchase

MBS5753070 is an inhibitor targeting EG00229.
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