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eIF4A3-IN-2 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753077

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 inhibitor with an IC50 of 110nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
eIF4A3-IN-2, Inhibitor
Full Product Name
eIF4A3-IN-2
Product Gene Name
eIF4A3-IN-2, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
602.7
Solubility
DMSO: 100mg/mL (165.92mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C25H19Br2ClN4O2
SMILES
O=C(C1=CC=C(Br)C=C1)N2CCN(C(C3=C4N(C=C(Br)C=C4)N=C3)=O)C[C@@H]2C5=CC=C(Cl)C=C5
CAS Number
2095677-20-4
Target & IC50
eIF4A3: ic50 110nM
In Vitro
eIF4A3-IN-2 binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay activities.

Structure of eIF4A3-IN-2, inhibitor

eIF4A3-IN-2 Inhibitor – Cat# MBS5753077

Product References and Citations for eIF4A3-IN-2, inhibitor

Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768.
Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768.

Other Notes

Small volumes of eIF4A3-IN-2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for eIF4A3-IN-2 purchase

MBS5753077 is an inhibitor targeting eIF4A3-IN-2.
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