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Elenbecestat Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753082

Elenbecestat is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment,of Alzheimer's disease. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Elenbecestat, Inhibitor
Full Product Name
Elenbecestat
Product Synonym Names
E2609
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
437.44
Solubility
DMSO: 250mg/mL (571.51mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H18F3N5O2S
SMILES
FC1=CC=C(NC(C2=NC=C(C(F)F)N=C2)=O)C=C1[C@@]3(N=C(N)SC4)[C@@]4([H])[C@@H](C)OC3
CAS Number
1388651-30-6
Target & IC50
BACE-1
In Vitro
E2609 (0.3-30mg/kg; p.o.) potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF of non-human primates.E2609 displays the plasma half-life of 12-16 hours after once daily dosing.

Structure of Elenbecestat, inhibitor

Elenbecestat Inhibitor – Cat# MBS5753082

Product References and Citations for Elenbecestat, inhibitor

Kumar D, et al.Secretase inhibitors for the treatment,of Alzheimer's disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-452.
Kumar D, et al.Secretase inhibitors for the treatment,of Alzheimer's disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-452.
A single dose of the beta-secretase inhibitor, e2609, decreases CSF bace1 enzymatic activity in cynomolgus monkeys. Alzheimer's & Dementia, 8(4), P224.
A single dose of the beta-secretase inhibitor, e2609, decreases CSF bace1 enzymatic activity in cynomolgus monkeys. Alzheimer's & Dementia, 8(4), P224.

Other Notes

Small volumes of Elenbecestat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Elenbecestat purchase

MBS5753082 is an inhibitor targeting Elenbecestat.
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