ELN318463 Inhibitor – ELN 318463

Name: ELN318463 Inhibitor; ELN 318463; MyBioSource
Brand: MyBioSource
SKU: MBS5753085
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753085

ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised gamma-secretase with EC50s of 12nM and 656nM for PS1and PS2, respectively. ELN318463 is 51-fold more selective for PS1. ELN 318463 racemate is the racemate of ELN 318463. ELN… More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ELN 318463 (ELN318463), Inhibitor

Full Product Name

ELN 318463 racemate

Product Gene Name

ELN318463, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

471.8

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C19H20BrClN2O3S

SMILES

O=S(C1=CC=C(Cl)C=C1)(N(CC2=CC=C(Br)C=C2)C3C(NCCCC3)=O)=O

CAS Number

851599-82-1

Target & IC50

gamma-secretase

In Vitro

ELN318463 is a typical xanthocervase inhibitor, which can only replace the active site-oriented inhibitor at very high concentrations in the presence of substrates.Compared with Notch signaling, ELN318463 is 75-120 times more selective in inhibiting acetaminophen production in cells.

Product References and Citations for ELN318463, inhibitor

Zhao B, et al. Identification of gamma-secretase inhibitor potency determinants on presenilin. J Biol Chem. 2008 Feb 1;283(5):2927-38.
Zhao B, et al. Identification of gamma-secretase inhibitor potency determinants on presenilin. J Biol Chem. 2008 Feb 1;283(5):2927-38.
Basi GS, et al. Amyloid precursor protein selective gamma-secretase inhibitors for treatment,of Alzheimer's disease. Alzheimers Res Ther. 2010 Dec 29;2(6):36.
Basi GS, et al. Amyloid precursor protein selective gamma-secretase inhibitors for treatment,of Alzheimer's disease. Alzheimers Res Ther. 2010 Dec 29;2(6):36.

Other Notes

Small volumes of ELN318463, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ELN318463 purchase

MBS5753085 is an inhibitor targeting ELN318463. Also known as ELN 318463 racemate.

ELN318463 Inhibitor – ELN 318463

Product Overview

Structure of ELN318463, inhibitor

Related Product Information for ELN318463, inhibitor

Product References and Citations for ELN318463, inhibitor

Other Notes

Searchable Terms for ELN318463 purchase