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Endoxifen E-isomer Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753097

(Z)-Endoxifen is an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen. Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Endoxifen E-isomer, Inhibitor
Full Product Name
Endoxifen E-isomer
Product Synonym Names
E-Endoxifen
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
373.49
Solubility
DMSO: 32mg/mL (85.68mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C25H27NO2
SMILES
OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1
CAS Number
114828-90-9
Target & IC50
Others
In Vitro
(E)-Endoxifen is identified as the primary degradant.Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser known (E)-isomer. It is assumed that (E)-Endoxifen, structurally related to (E)-4-OH-tamoxifen, have similar pharmacological properties. The (E)-isomer is an impurity in (Z)-Endoxifen drug substance and increases under certain storage conditions.

Structure of Endoxifen E-isomer, inhibitor

Endoxifen E-isomer Inhibitor – Cat# MBS5753097

Product References and Citations for Endoxifen E-isomer, inhibitor

Elkins P, et al. Characterization of the isomeric configuration and impurities of (Z)-Endoxifen by 2DnMR, high resolution LC-MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.
Elkins P, et al. Characterization of the isomeric configuration and impurities of (Z)-Endoxifen by 2DnMR, high resolution LC-MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.

Other Notes

Small volumes of Endoxifen E-isomer, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Endoxifen E-isomer purchase

MBS5753097 is an inhibitor targeting Endoxifen E-isomer.
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